Precision Powder Handling for a Regulated Environment
In pharmaceutical manufacturing, powder handling must meet the highest standards for containment, cleanliness, accuracy, and repeatability. Whether processing high-potency APIs, excipients, or complex blends, every step — from mixing to transfer and discharge — must be controlled and validated.
The Cone Valve IBC system is designed to deliver the highest levels of containment, blend integrity, and powder flow control for regulated pharmaceutical environments. With GMP-compliant construction, dust-free transfer, and segregation-free discharge, it supports safe and repeatable production in both oral solid dosage (OSD) and specialty pharma applications.
Key Benefits for Pharmaceutical Manufacturers
🚿 GMP-Compliant Design
Cone Valve IBC systems are built with hygienic, pharmaceutical-grade materials, ensuring full compliance with cGMP and regulatory requirements.
Benefits:
- 316L stainless steel construction
- Crevice-free, easy-clean design
- FDA-compliant seals and contact materials
- Validated cleaning (CIP/WIP compatible)
🧤 High Containment for HPAPIs and Toxic Powders
The system offers closed, dust-tight powder handling, ideal for high-potency active pharmaceutical ingredients (HPAPIs) and operator protection.
Benefits:
- OEB 3–5 containment levels achievable
- Minimise operator exposure
- Eliminate dust generation and cross-contamination
- Complies with occupational exposure limits (OELs)
🛡️️ Mass Flow Discharge – No Segregation
Traditional discharge methods often cause powder de-mixing. The Cone Valve ensures mass flow, discharging all materials uniformly.
Benefits:
- Maintains blend homogeneity
- Avoids fines/flushing at the start and coarse particles at the end
- Eliminates need for post-transfer re-mixing
- Supports assured dose uniformity
⚙️ In-Bin Blending (Dry Mixing)
Powders can be blended directly inside the IBC, eliminating the need to transfer between vessels — a critical advantage in high-containment environments.
Benefits:
- Fewer equipment cleaning validations
- No open transfer points
- Reduced cross-contamination risk
- Preserves blend uniformity through to final dose
🛢️️ Dust-Free Transfer & Discharge
Cone Valve IBCs operate as sealed units throughout processing — including filling, blending, and discharging — reducing contamination risks.
Benefits:
- Improves cleanroom performance
- Protects surrounding areas from airborne powder
- Supports ISO Class 5–8 environments
- Simplifies HVAC and dust extraction requirements
⚙️ Handles Challenging Pharmaceutical Powders
The system effectively handles powders with poor flowability, electrostatic properties, or fragility — without the need for external vibration or air fluidisation.
Typical Materials:
- Microcrystalline cellulose
- Lactose
- Spray-dried APIs
- Magnesium stearate
- Granules and co-processed excipients
♻️ Complete Discharge with Minimal Residue
Cone Valve technology allows nearly 100% product recovery — essential when working with expensive or potent materials.
Benefits:
- Increases yield from each batch
- Reduces material loss and contamination risk
- Minimises manual handling and waste cleaning
🧪 Fast, Validated Cleaning & Batch Changeovers
Cleaning is simple, effective, and repeatable. IBCs can be wet or dry cleaned offline without affecting production schedules.
Benefits:
- Offline cleaning ensures continuous production
- Shortens validation cycles
- Enables multi-product manufacturing lines
- Compatible with automated WIP/CIP systems
🏭 Applications Across Pharmaceutical Manufacturing
- Oral solid dosage forms (OSD)
- High-potency APIs (HPAPIs)
- Nutraceuticals & dietary supplements
- Excipients and intermediates
- Powder-to-pack processes
- Batch processing lines
Trusted by Pharmaceutical Manufacturers Across Southeast Asia
Cone Valve IBC systems are supporting GMP-certified facilities throughout Singapore, Malaysia, the Philippines, Thailand, Indonesia, and Vietnam, helping local and multinational pharmaceutical companies meet regulatory compliance while improving efficiency and safety.
Protect People, Products, and Processes
With our Cone Valve IBC systems, pharmaceutical companies benefit from:
- ✅ GMP- and FDA-compliant design
- ✅ Contained, dust-free powder handling
- ✅ No segregation during discharge
- ✅ High containment for potent compounds
- ✅ In-bin blending for batch integrity
- ✅ Efficient cleaning and fast changeovers
- ✅ Modular system integration (automation & PAT-ready)
📞 Speak to a Pharma Powder Handling Expert
📧 Email: info@conebox.co
📞 Call: +65 8678 3109 (WhatsApp) / +6010 246 2478
🌐 Request a Technical Consultation: [Insert Link]
💡 Cleaner. Safer. Smarter.
Cone Valve IBC systems — engineered for excellence in pharmaceutical powder handling.
CONEBOX PTE. LTD. (202326932E)
160 Robinson Road, #14-04 Singapore Business Federation Center, Singapore 068914
Tel (SG): + 65 8678 3109 (Whatsapp)
Tel (MY): + 6010 246 2478
Website: www.conebox.co
Email: info@conebox.co
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